Novel lipids contributed less to CVD risk reduction compared with traditional lipids (15.5% and 19.1%, respectively). When sets of risk factors were examined, inflammatory/hemostatic biomarkers made the largest contribution to lower risk (32.6%), followed by blood pressure (27.1%). Differences in known risk factors explained a large proportion (59.0%) of the observed inverse association. Using the reference group of <200 kcal/wk of activity yielded age- and treatment-adjusted relative risk reductions associated with 200 to 599, 600 to 1499, and ≥1500 kcal/wk of 27%, 32%, and 41%, respectively. The risk of CVD decreased linearly with higher levels of activity ( P for linear trend <0.001). Mean follow-up was 10.9☑.6 years, and 979 incident CVD events occurred. Methods and Results- In a prospective study of 27 055 apparently healthy women, we measured baseline levels of hemoglobin A1c, traditional lipids (total, low-density lipoprotein, and high-density lipoprotein cholesterol), novel lipids, creatinine, homocysteine, and inflammatory/hemostatic biomarkers (high-sensitivity C-reactive protein, fibrinogen, soluble intracellular adhesion molecule-1) and used women’s self-reported physical activity, weight, height, hypertension, and diabetes. Although the precise mechanisms underlying this inverse association are unclear, differences in several cardiovascular risk factors may mediate this effect. Customer Service and Ordering Informationīackground- Higher levels of physical activity are associated with fewer cardiovascular disease (CVD) events.Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).
Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).
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